Neurobiology of Disease Common Alzheimer’s Disease Risk Variant within the CLU Gene Affects White Matter Microstructure in Young Adults
نویسندگان
چکیده
Meredith N. Braskie,1* Neda Jahanshad,1,2* Jason L. Stein,1* Marina Barysheva,1 Katie L. McMahon,4 Greig I. de Zubicaray,5 Nicholas G. Martin,6 Margaret J. Wright,6 John M. Ringman,3 Arthur W. Toga,1 and Paul M. Thompson1 1Laboratory of Neuro Imaging, Department of Neurology, 2Medical Imaging Informatics, Department of Radiology, and 3Mary S. Easton Center for Alzheimer’s Disease Research, Department of Neurology, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095, 4Centre of Advanced Imaging and 5School of Psychology, University of Queensland, Brisbane, Queensland 4072, Australia, and 6Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
منابع مشابه
Common Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adults.
There is a strong genetic risk for late-onset Alzheimer's disease (AD), but so far few gene variants have been identified that reliably contribute to that risk. A newly confirmed genetic risk allele C of the clusterin (CLU) gene variant rs11136000 is carried by ∼88% of Caucasians. The C allele confers a 1.16 greater odds of developing late-onset AD than the T allele. AD patients have reductions...
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Meredith N. Braskie,1 Neda Jahanshad,1,2 Jason L. Stein,1 Marina Barysheva,1 Kori Johnson,4,6 Katie L. McMahon,4 Greig I. de Zubicaray,5 Nicholas G. Martin,6 Margaret J. Wright,6 John M. Ringman,3 Arthur W. Toga,1 and Paul M. Thompson1 1Laboratory of Neuro Imaging, Department of Neurology and 2Medical Imaging Informatics Group, Department of Radiology, University of California, Los Angeles (UCL...
متن کاملA gene-brain-cognition pathway for the effect of an Alzheimer׳s risk gene on working memory in young adults.
Identifying pathways by which genetic Alzheimer׳s disease (AD) risk factors exert neurocognitive effects in young adults are essential for the effort to develop early interventions to forestall or prevent AD onset. Here, in a brain-imaging cohort of 59 young adults, we investigated effects of a variant within the clusterin (CLU) gene on working memory function and gray matter volume in cortical...
متن کاملGenetically-mediated Grey and White Matter Alteration in Normal Elderly Individuals with the CLU-C Allele Gene
BACKGROUND Several genome-wide association studies have found that the rs11136000 polymorphism of the C allele (CLU-C) is associated with the risk for developing late-onset Alzheimer's disease (LOAD). However, the effects of the CLU-C/C genotype on brain structure, including gray and white matter, are not adequately understood. OBJECTIVES We aimed to clarify the gray matter and white matter i...
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